PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

Chris D. Ellson, Stéphanie Gobert-Gosse, Karen E. Anderson, +12

Nature Cell Biology

InflammationSignal TransductionBiochemistryNatural SciencesLipid Peroxidation +9

Identification of ARAP3, a Novel PI3K Effector Regulating Both Arf and Rho GTPases, by Selective Capture on Phosphoinositide Affinity Matrices

Sonja Krugmann, Karen E. Anderson, S H Ridley, +22

Molecular Cell

Selective CaptureSignal TransductionProtein FunctionBiochemistryRho Gtpases +8

Neutrophils from p40<i>phox−/−</i> mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

Chris D. Ellson, Keith Davidson, Gail Ferguson, +3

The Journal of Experimental Medicine

Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils

Sabine Suire, Alison M. Condliffe, Gail Ferguson, +9

Nature Cell Biology

InflammationSignal TransductionMolecular PhysiologyGranulocyteImportant Regulators +7

p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ

Sabine Suire, John Coadwell, Gail Ferguson, +3

Current Biology

Molecular PhysiologySignal TransductionSignaling PathwayG Protein-coupled ReceptorReceptor (Biochemistry) +7

PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes

Suhasini Kulkarni, Cassian Sitaru, Zoltán Jakus, +19

Science Signaling

PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation

Chris D. Ellson, Keith Davidson, Karen E. Anderson, +2

The EMBO Journal

Reductive StressMolecular PhysiologySignal TransductionBiochemistryNatural Sciences +11

FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments

S H Ridley, Nicholas T. Ktistakis, Keith Davidson, +15

Journal of Cell Science

Fyve DomainsMolecular BiologyIntact Fyve DomainEarly EndosomesEndocytic Pathway +14

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks

Karen E. Anderson, Keith B. Boyle, Keith Davidson, +8

Blood

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

Sabine Suire, Charlotte Lécureuil, Karen E. Anderson, +8

The EMBO Journal

InflammationNeutrophils DependsSignal TransductionMolecular PhysiologyBiochemistry +11