Francis C. Luca

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Valery Sudakin, D Ganoth, Aviva Dahan et al. · Molecular Biology of the Cell · 1995 · 753 citations · Full text

Ubiquitin-mediated Degradation, Protein Function, Cell Regulation +15

Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption

Kevin Hardwick, Eric L. Weiss, Francis C. Luca et al. · Science · 1996 · 335 citations

Molecular Biology, Cytoskeleton, Cell Cycle +16

The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.

Tim Hunt, Francis C. Luca, Joan Ruderman · The Journal of Cell Biology · 1992 · 235 citations · Full text

Oocyte, Genetics, Molecular Biology +22

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

Avram Hershko, D Ganoth, Valery Sudakin et al. · Journal of Biological Chemistry · 1994 · 233 citations · Full text

Molecular Regulation, Molecular Biology, Cytoskeleton +18

RAM: A Conserved Signaling Network That Regulates Ace2p Transcriptional Activity and Polarized Morphogenesis

Bryce Nelson, Cornelia Kurischko, Joe Horecka et al. · Molecular Biology of the Cell · 2003 · 228 citations · Full text

Molecular Regulation, Genetics, Conserved Signaling Network +18