Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme

R. D. Banks, C. C. F. Blake, P. R. Evans, +5

Nature

Cellular EnzymologyBiochemistryNatural SciencesPhosphoglycerate KinaseMolecular Biology +3

Structural requirements for opioid activity of analogues of the enkephalins

C.R. Beddell, Robert B. Clark, George W. Hardy, +7

Proceedings of the Royal Society of London. Series B, Biological sciences

Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides

Shahnaz Rahim, Naimisha Trivedi, Mirjana V. Bogunovic-Batchelor, +9

Journal of Medicinal Chemistry

Medicinal ChemistrySynthetic VirologyMedicineNatural SciencesVaricella Zoster Virus +11

Discovery of Further Pyrrolidine <i>trans</i>-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison, +15

Journal of Medicinal Chemistry

Crystal StructurePharmaceutical ScienceHne ComplexedPharmacotherapyChemical Biology +14

Conformation of two 4'-thio-2'-deoxynucleoside analogs studied by 5000-MHz proton NMR spectroscopy and x-ray crystallography.

Léo H. Koole, Janez Plavec, Hongying Liu, +7

Journal of the American Chemical Society

X-ray CrystallographyBiochemistryPhysicsDonut IconNatural Sciences +12

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate

Simon J. F. Macdonald, Michael D. Dowle, Lee A. Harrison, +19

Bioorganic & Medicinal Chemistry Letters

InflammationGranulocyteDevelopment CandidateMedicineImmunology +5

Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions

R.L. Follenfant, George W. Hardy, L. A. LOWE, +2

British Journal of Pharmacology

Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity

Keith Biggadike, Mohamed Boudjelal, Margaret Clackers, +16

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMmtv AgonismBiochemistryNonsteroidal Glucocorticoid +12

Non-steroidal glucocorticoid agonists—The discovery of aryl pyrazoles as A-ring mimetics

Margaret Clackers, Diane M. Coe, Derek A. Demaine, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBioorganic ChemistryBiochemistryAryl PyrazolesMedicine +9

β-Anomer selectivity in 2′-deoxynucleoside synthesis: A novel approach using an acyl carbamate directing group

Robert J. Young, Sue Shaw-Ponter, George W. Hardy, +1

Tetrahedron Letters

Enantioselective SynthesisEngineering2′-Deoxynucleoside SynthesisBiochemistryNovel Approach +5