Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Andrew L. Kung, Sonya Zabludoff, Dennis S. France, +14

Cancer Cell

Transcriptional CoactivationTranscriptional RegulationRedox RegulatorHypoxia (Medicine)Gene Expression +7

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

Steven J. Freedman, Zhenyu Sun, Florence Poy, +4

Proceedings of the National Academy of Sciences

Signal TransductionP300 BoundBiochemistryRedox RegulatorProtein Folding +10

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

Francis J. Giles, Jörge E. Cortes, Dan Jones, +3

Blood

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

Ian E. Krop, Tim Demuth, Tina Guthrie, +17

Journal of Clinical Oncology

Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2

Steven J. Freedman, Zhenyu Sun, Andrew L. Kung, +3

Nature Structural & Molecular Biology

Transcriptional RegulationSignal TransductionBiochemistryPhysiologyHypoxia (Medicine) +7

Identification of the Phospholipid Binding Site in the Vitamin K-dependent Blood Coagulation Protein Factor IX

Steven J. Freedman, Mark Blostein, James Baleja, +3

Journal of Biological Chemistry

Histiocytosis-X: <i>In Situ</i> Characterization of Cutaneous Infiltrates with Monoclonal Antibodies

Terence J. Harrist, Atul K. Bhan, Gëorge F. Murphy, +5

American Journal of Clinical Pathology

Structure of the Calcium Ion-Bound .gamma.-Carboxyglutamic Acid-Rich Domain of Factor IX

Steven J. Freedman, Barbara C. Furie, B Furie, +1

Biochemistry

Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors

Anne M. Traynor, Maureen R. Hewitt, Glenn Liu, +9

Cancer Chemotherapy and Pharmacology

OncologyMedicineAdult PatientsAdvanced Solid TumorsImmune Checkpoint Inhibitor +5

Structure of the Metal-free γ-Carboxyglutamic Acid-rich Membrane Binding Region of Factor IX by Two-dimensional NMR Spectroscopy

Steven J. Freedman, Barbara C. Furie, Bruce Furie, +1

Journal of Biological Chemistry

Factor IxProteinlipid InteractionProtein AssemblyPeptide EngineeringMolecular Biology +17