Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

Shashi Kumar Gupta, Masao Hirota, Sheela Waugh, +12

Journal of Biological Chemistry

InflammationCytokineImmunologyMolecular BiologyImmunologic Mechanism +6

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

Amy D. Gelinas, D.R. Davies, Thomas E. Edwards, +9

Journal of Biological Chemistry

CytokineMolecular ImmunologyCrystal StructureNucleic Acid ChemistryNatural Sciences +7

Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

Ruimin Ge, Daniel Tornero, Masao Hirota, +4

Journal of Neuroinflammation

Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: Utilization of polyamines and bile acids

Masateru Miyake, Takanori Minami, Masao Hirota, +5

Journal of Controlled Release

Pharmaceutical ScienceMedicineDigestive TractDrug AbsorptionPharmacology +3

Chemically Modified Interleukin-6 Aptamer Inhibits Development of Collagen-Induced Arthritis in Cynomolgus Monkeys

Masao Hirota, Ikuo Murakami, Yuichi Ishikawa, +9

Nucleic Acid Therapeutics

ImmunologyInflammatory ArthritisInflammationRheumatoid DisorderSomamer Treatment +16

Pharmacokinetic Properties of DNA Aptamers with Base Modifications

Shashi Kumar Gupta, Daniel W. Drolet, Steven K. Wolk, +11

Nucleic Acid Therapeutics

Molecular BiologyPeptide ScienceAnalytical UltracentrifugationChemical BiologyMolecular Pharmacology +19

Cytokine regulation of PS2 gene expression in mouse astrocytes.

Masao Hirota, Hirofumi Awatsuji, Yoshiko Furukawa, +1

PubMed

ImmunologyCell DeathPs2 Gene ExpressionCellular PhysiologyNeuroinflammation +14

pS2 gene especially expressed in the late G1/S phase of mouse astrocytes

Masao Hirota, Sadakazu Miyashita, Hiroki Hayashi, +2

Neuroscience Letters

Molecular NeuroscienceMolecular PhysiologyDevelopmental BiologySignal TransductionCell Signaling +11

Interferons Suppress Nerve Growth Factor Synthesis as a Result of Interference with Cell Growth in Astrocytes Cultured from Neonatal Mouse Brain

Hirofumi Awatsuji, Yoshiko Furukawa, Masao Hirota, +2

Journal of Neurochemistry

Effect of Basic Fibroblast Growth Factor on Synthesis/Secretion of pS2 Protein by Human Breast Cancer Cells (MCF‐7)

Sadakazu Miyashita, Masao Hirota, Toshiya Yamamoto, +3

European Journal of Biochemistry