A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion.

Masaaki Moroi, Stéphanie Jung, M Okuma, +1

Journal of Clinical Investigation

Collagen ReceptorImmunologyGlycoprotein ViPathologyInflammation +19

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

Takako Hirata, Fumitaka Ushikubi, Akira Kakizuka, +2

Journal of Clinical Investigation

ImmunologyPathologyThromboxane A2Molecular PharmacologyThrombosis +16

A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia

T Sugiyama, M Okuma, Fumitaka Ushikubi, +3

Blood

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

Takako Hirata, Akira Kakizuka, Fumitaka Ushikubi, +3

Journal of Clinical Investigation

ThrombopoiesisThrombosisSignal TransductionInherited Human DisordersBlood Platelet +13

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets

Fumitaka Ushikubi, Masatoshi Nakajima, M. Hirata, +3

Journal of Biological Chemistry

Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets.

T Yoshimoto, Shogo Yamamoto, M Okuma, +1

Journal of Biological Chemistry

Platelet BiologyThrombosisThrombopoiesisBiochemistryBlood Platelet +12

Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders

M Okuma, Haruto Uchino

Blood

Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling.

Nobuyoshi Arima, M Kamio, Kazunori Imada, +5

The Journal of Experimental Medicine

Third ComponentImmune RegulationImmunologyImmunologic MechanismIl-2r Alpha +16

Expression of alpha-(1,3)-fucosyltransferases which synthesize sialyl Le(x) and sialyl Le(a), the carbohydrate ligands for E- and P-selectins,in human malignant cell lines.

Kazuhiro Yago, K Zenita, Harumi Ginya, +5

PubMed

OncologyBiochemistrySialyl LeLeukemia Cell LinesMedicine +13

Studies on lipid peroxides in platelets. I. Method of assay and effect of storage.

M Okuma, M. Steiner, M Baldini

PubMed

Blood PlateletMedicineLipid PeroxidationPlatelet ConcentratesPharmacology +2