Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Enza Maria Valente, Patrick M. Abou‐Sleiman, Viviana Caputo, +18

Science

Neurodegenerative DiseasesMitophagyMitochondrial FunctionDegenerative DiseasesDopaminergic Neurons +12

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

Daniel G. Healy, Mario Falchi, Sean S. O’Sullivan, +22

The Lancet Neurology

A common LRRK2 mutation in idiopathic Parkinson's disease

William P. Gilks, Patrick M. Abou‐Sleiman, Sonia Gandhi, +12

The Lancet

Mendelian DisorderParkinson DiseasePathologyDisease Gene IdentificationMedicine +1

The role of pathogenic <i>DJ‐1</i> mutations in Parkinson's disease

Patrick M. Abou‐Sleiman, Daniel G. Healy, Niall Quinn, +2

Annals of Neurology

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

Naheed L. Khan, Shushant Jain, John Lynch, +24

Brain

Motor DysfunctionNeurological DisorderCorticobasal DegenerationGeneticsPathology +20

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

Miratul M. K. Muqit, Patrick M. Abou‐Sleiman, Adrian T. Saurin, +15

Journal of Neurochemistry

MitophagyProteasomeMolecular BiologyPink1 ProteinCytoskeleton +15

A heterozygous effect for PINK1 mutations in Parkinson's disease?

Patrick M. Abou‐Sleiman, Miratul M. K. Muqit, Neil Q. McDonald, +10

Annals of Neurology

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

Tatiana D. Papkovskaia, Kai‐Yin Chau, Francisco Iñesta-Vaquera, +8

Human Molecular Genetics

MitophagyMolecular BiologyPathologyOxidative StressAutophagy +14

Parkin Disease

Karen A. Doherty, Laura Silveira‐Moriyama, Laura Parkkinen, +13

JAMA Neurology

Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

Selina Wray, Matthew W. Self, Patrick A. Lewis, +41

PLoS ONE

EngineeringMutation-defined Cell LinesDisease Gene IdentificationNeurobiology Of DiseaseMendelian Disorder +22