IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

Laura Belloni, Lena Allweiss, Francesca Guerrieri, +7

Journal of Clinical Investigation

Viral ReplicationActive CccdnaImmunologyMolecular BiologyCell Culture +20

Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B

Karsten Wursthorn, Marc Lütgehetmann, Maura Dandri, +11

Hepatology

Repopulation of Mouse Liver With Human Hepatocytes And In Vivo Infection With Hepatitis B Virus

Maura Dandri, Martin R. Burda, É Török, +9

Hepatology

Combination of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B

Patrick Marcellin, Sang Hoon Ahn, Xiaoli Ma, +26

Gastroenterology

Seven-Year Efficacy and Safety of Treatment with Tenofovir Disoproxil Fumarate for Chronic Hepatitis B Virus Infection

Naoky Tsai, Joerg Petersen, Robert Flisiak, +10

Digestive Diseases and Sciences

Impaired Intrahepatic Hepatitis B Virus Productivity Contributes to Low Viremia in Most HBeAg-Negative Patients

Tassilo Volz, Marc Lütgehetmann, P. Wachtler, +5

Gastroenterology

Hepatitis DViral PersistenceHepatologyMost Hbeag-negative PatientsViral Hepatitis +8

Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis

Roeland Zoutendijk, Jurriën G.P. Reijnders, Fabien Zoulim, +11

Gut

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo

Lena Allweiss, Tassilo Volz, Katja Giersch, +9

Gut

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism

Nicola Oehler, Tassilo Volz, Oliver D. Bhadra, +13

Hepatology

Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice

Marc Lütgehetmann, Till Bornscheuer, Tassilo Volz, +6

Gastroenterology

HepatologyViral HepatitisLiver PhysiologyImmunologyHepatitis B +9