Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Claudia Lütticken, Ursula Maria Wegenka, Juping Yuan, +13

Science

ImmunologyTranscription Factor AprfImmunologic MechanismInflammationSignaling Pathway +16

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Mathias Müller, James Briscoe, Carl Laxton, +12

Nature

Complement SystemSignal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunology +7

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

Ke Shuai, Andrew Ziemiecki, Andrew F. Wilks, +4

Nature

Tyrosine PhosphorylationSignal TransductionStat ProteinsSignaling PathwayReceptor Tyrosine Kinase +6

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

Andrew F. Wilks, Ailsa G. Harpur, Raja R. Kurban, +3

Molecular and Cellular Biology

Protein FunctionSignal TransductionSignaling PathwayBiochemistryNatural Sciences +13

JAK2, a third member of the JAK family of protein tyrosine kinases.

Ailsa G. Harpur, A.‐C. Andres, Andrew Ziemiecki, +2

PubMed

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

Kazuhiko Igarashi, Gianni Garotta, Laurence Ozmen, +5

Journal of Biological Chemistry

ImmunologyImmunologic MechanismLigand BindingInterferon-gamma ReceptorCellular Physiology +16

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

Sandra E. Nicholson, Andrew C. Oates, Ailsa G. Harpur, +3

Proceedings of the National Academy of Sciences

Tyrosine Kinase Jak1ImmunologyImmune RegulationPathologyImmunologic Mechanism +21

Imaging FRET between spectrally similar GFP molecules in single cells

Ailsa G. Harpur, Fred S. Wouters, Philippe I. H. Bastiaens

Nature Biotechnology

Fluorescence MicroscopyEngineeringNovel Imaging MethodBiomedical ImagingMolecular Biology +9

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

James Briscoe, Neil C. Rogers, Bruce A. Witthuhn, +6

The EMBO Journal

Signal TransductionMolecular VirologyViral ImmunityImmunologyAntiviral Response +10

Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells.

Isabelle Dusanter‐Fourt, O. Müller, Andrew Ziemiecki, +7

The EMBO Journal

Signal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunologyTyrosine Kinases +6