Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

Yasuyuki Fujii, Takehiro Hirayama, Hidenori Ohtake, +11

The Journal of Immunology

ImmunologyImmunologic MechanismImmunotherapyInflammatory ArthritisInflammation +21

Palladiurn(<scp>0</scp>)-catalysed transfer hydrogenation of alkynes to cis-alkenes with HCO₂H–NEt₃

Kousuke Tani, Naoya Ono, Sentaro Okamoto, +1

Journal of the Chemical Society Chemical Communications

Chemical EngineeringTransfer HydrogenationEngineeringCross-coupling ReactionOrganic Chemistry +7

Eicosanoid Regulation of Vascular Endothelial Growth Factor Expression and Angiogenesis in Microvessel Endothelial Cells

Alexandre Mezentsev, Francesca Seta, Michael W. Dunn, +3

Journal of Biological Chemistry

20-Hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction

Ming Yu, Magdalena Alonso‐Galicia, Chengwen Sun, +11

Bioorganic & Medicinal Chemistry

Renal FunctionMedicinePhysiologyRenal PathophysiologyPharmacology +4

A highly practical synthesis of natural PGE1, Δ2-trans-PGE1 and 2,2,3,3-tetradehydro-PGE1 via two-component coupling process using zinc-copper reagents

H. TSUJIYAMA, Naoya Ono, Toshiharu Yoshino, +2

Tetrahedron Letters

Chemical EngineeringZinc-copper ReagentsPractical SynthesisEngineeringCross-coupling Reaction +4

Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice

Iwao Arai, Akiko Takaoka, Yuki Hashimoto, +12

European Journal of Pharmacology

InflammationAtopic DermatitisImmunologySkin AllergyExperimental Pruritus +5

5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors

Hideaki Amada, Yoshinori Sekiguchi, Naoya Ono, +10

Bioorganic & Medicinal Chemistry

-1H-imidazole DerivativesMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis

Yasuyuki Fujii, Yasuji Ueda, Hidenori Ohtake, +5

Biochemical and Biophysical Research Communications

Signal TransductionAngiogenesisMedicineEndothelial DysfunctionVascular Biology +5

Radical Addition Reactions to Allylstannanes Having Substituents at C-1. Highly Efficient Synthesis of Enantiomerically Pure .alpha.-Alkylcyclopentenones, the Key Component for Synthesis of Prostaglandins by the Two-Component Coupling Process

Yukio Yoshida, Naoya Ono, Fumie Sato

The Journal of Organic Chemistry

EngineeringEnantiomerically Pure .Alpha.-alkylcyclopentenonesAltmetric Attention ScoreOrganic ChemistryRadical Addition Reactions +10

Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-β type I receptor kinase

Hideaki Amada, Yoshinori Sekiguchi, Naoya Ono, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel 4-ThiazolylimidazolesBiochemistryNatural SciencesMedicine +6