Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo

Byeong‐Woo Park, Hongtao Zhang, Chuan-Jin Wu, +8

Nature Biotechnology

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

J-M Huang, Izumi Nagatomo, Emi Suzuki, +7

Oncogene

Tumor BiologySignal TransductionSignaling PathwaySurvivin InhibitorsMedicine +8

Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope

Zhaocai Zhou, Xiulian Du, Zheng Cai, +11

Journal of Biological Chemistry

BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors.

Natalie Minkovsky, Alan Berezov

PubMed

Solid TumorsPathologyNsclc TumorsTumor BiologyOncology +14

Disabling ErbB Receptors with Rationally Designed Exocyclic Mimetics of Antibodies:  Structure−Function Analysis

Alan Berezov, Hongtao Zhang, Mark I. Greene, +1

Journal of Medicinal Chemistry

Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function

Xiaomin Song, Bin Li, Yan Xiao, +15

Cell Reports

Crystal StructureMolecular RegulationT-regulatory CellBiological FeaturesMolecular Biology +17

Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics

Alan Berezov, Jinqiu Chen, Qingdu Liu, +3

Journal of Biological Chemistry

Tumor BiologyReceptor Tyrosine KinaseCell SignalingPotential Dimerization SurfacesReceptor Ensembles +14

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma

S N Brun, Shirley L. Markant, Lourdes Adriana Esparza, +15

Oncogene

Neuro-oncologyTumoral PathologyPathologyMedicineCell Biology +1

Suppression by human FOXP3 ⁺ regulatory T cells requires FOXP3-TIP60 interactions

Khalid Bin Dhuban, Eva d’Hennezel, Yasuhiro Nagai, +14

Science Immunology

Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states

Zhaocai Zhou, Xiaomin Song, Alan Berezov, +6

Proceedings of the National Academy of Sciences

Protein AssemblyImmunologyGlycobiologyMolecular BiologyMultiple Oligomerization States +20