Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

Kosei Eguchi, Ichiro Manabe, Yumiko Tanaka, +11

Cell Metabolism

InflammationMetabolic SyndromeInsulin SignalingPhysiologyImmunology +10

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

Norifumi Takeda, Ichiro Manabe, Yuichi Uchino, +9

Journal of Clinical Investigation

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

Amir Tirosh, Ediz S. Calay, Gürol Tuncman, +13

Science Translational Medicine

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Alexander Bartelt, Scott B. Widenmaier, Christian Schlein, +16

Nature Medicine

Nrf1-mediated Proteasomal ActivityPhysiologyMetabolic SignalingMetabolic RegulationMetabolic Remodeling +3

Bone Marrow–Derived Cells Contribute to Vascular Inflammation but Do Not Differentiate Into Smooth Muscle Cell Lineages

Hiroshi Iwata, Ichiro Manabe, Katsuhito Fujiu, +7

Circulation

Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin

Yuji Ogawa, Kento Imajo, Yasushi Honda, +14

Scientific Reports

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

Suneng Fu, Abdullah Yalçın, Grace Y. Lee, +6

Science Translational Medicine

Pre-operative atrial fibrillation as the key determinant of outcome of mitral valve repair for degenerative mitral regurgitation

Kosei Eguchi, Eiji Ohtaki, Takayoshi Matsumura, +9

European Heart Journal

Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

M. Furkan Burak, Karen Inouye, Ariel White, +17

Science Translational Medicine

A hormone complex of FABP4 and nucleoside kinases regulates islet function

Kacey J. Prentice, Jani Saksi, Lauren Robertson, +11

Nature

Islet FunctionSignal TransductionMolecular PhysiologyEndocrine MechanismMolecular Pathway +12