Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess, +28

ACS Medicinal Chemistry Letters

Highly Potent InhibitorTumor BiologyMammalian TargetSignaling PathwayCancer Cell Biology +14

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Kenneth W. Wood, Latesh Lad, Lusong Luo, +32

Proceedings of the National Academy of Sciences

Antitumor ActivityCenp-e Motor ActivityMolecular BiologyCell DeathCytoskeleton +16

Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

Zhihong Lai, Katherine V. Ferry, Melody Diamond, +7

Journal of Biological Chemistry

Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis

Aidan G. Gilmartin, Maureen R. Bleam, Mark C. Richter, +11

Cancer Research

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

Zhihong Lai, Tao Yang, Young B. Kim, +8

Proceedings of the National Academy of Sciences

Vitro Enzyme AssayMolecular BiologyHdm2-mediated P53 UbiquitinationChemical BiologyCancer Biology +17

Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

Charles F. Albright, Nilsa Graciani, Wei Han, +27

Molecular Cancer Therapeutics

ImmunologyMmp-selective MetabolismPharmacotherapyTumor BiologyDrug Resistance +18

Novel ATP-Competitive Kinesin Spindle Protein Inhibitors

Cynthia A. Parrish, Nicholas D. Adams, Kurt R. Auger, +25

Journal of Medicinal Chemistry

Protein FunctionBiochemistryMedicineMacromolecular MachineSpindle Pole Separation +13

Efficacy of DMP 840: a novel bis-naphthalimide cytotoxic agent with human solid tumor xenograft selectivity.

R. J. McRipley, P E Burns-Horwitz, P M Czerniak, +7

PubMed

Medicinal ChemistryDrug TargetingOncologyNovel TherapyMedicine +13

Abstract 4712: Discovery of INCB059872, a novel FAD-directed LSD1 inhibitor that is effective in preclinical models of human and murine AML

Sang‐Hyun Lee, Matthew C. Stubbs, Xuesong Mike Liu, +18

Cancer Research

Histone ModificationsDrug TargetMixed-phenotype Acute LeukemiaEpigenetic ChangeMurine Aml +23

Chemotherapy of mammary carcinomas arising in ras transgenic mice

Daniel L. Dexter, Melody Diamond, Janet Creveling, +1

Investigational New Drugs

Breast OncologyMammary GlandRas Transgenic MicePathologyBreast Cancer +3