Simin Lu

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Christine M. Oslowski, Takashi Hara, Bryan O’Sullivan-Murphy et al. · Cell Metabolism · 2012 · 670 citations · Full text

Inflammation, Signal Transduction, Medicine +10

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Sonya G. Fonseca, Shinsuke Ishigaki, Christine M. Oslowski et al. · Journal of Clinical Investigation · 2010 · 394 citations · Full text

Genetics, Er Stress, Insulin Signaling +18

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Simin Lu, Kohsuke Kanekura, Takashi Hara et al. · Proceedings of the National Academy of Sciences · 2014 · 148 citations · Full text

Calcium-dependent Protease, Apoptosis, Calpain 2 +25

Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death

Takashi Hara, Jana Mahadevan, Kohsuke Kanekura et al. · Endocrinology · 2014 · 144 citations · Full text

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Lori L. Bonnycastle, Peter S. Chines, Takashi Hara et al. · Diabetes · 2013 · 118 citations · Full text

Wolfram Syndrome 1, Genetics, Genetic Epidemiology +18