Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Christine M. Oslowski, Takashi Hara, Bryan O’Sullivan-Murphy, +11

Cell Metabolism

InflammationSignal TransductionMedicineApoptosisImmunology +8

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Sonya G. Fonseca, Shinsuke Ishigaki, Christine M. Oslowski, +8

Journal of Clinical Investigation

GeneticsEr StressInsulin SignalingEr Stress SignalingOxidative Stress +16

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Simin Lu, Kohsuke Kanekura, Takashi Hara, +15

Proceedings of the National Academy of Sciences

Calcium-dependent ProteaseApoptosisCalpain 2Cell DeathCytoskeleton +23

Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death

Takashi Hara, Jana Mahadevan, Kohsuke Kanekura, +3

Endocrinology

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Lori L. Bonnycastle, Peter S. Chines, Takashi Hara, +15

Diabetes

Wolfram Syndrome 1GeneticsGenetic EpidemiologyPathologyUnaffected Family Members +16

Characterization of Treponema pallidum Dissemination in C57BL/6 Mice

Simin Lu, Kang Zheng, Jianye Wang, +5

Frontiers in Immunology

Treponema pallidum Tp0751 alters the expression of tight junction proteins by promoting bEnd3 cell apoptosis and IL-6 secretion

Simin Lu, Jianye Wang, Zhangping He, +5

International Journal of Medical Microbiology

A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome

Jana Mahadevan, Shuntaro Morikawa, Takuya Yagi, +5

Laboratory Investigation

ApoptosisPathologyCell DeathSynaptic SignalingSocial Sciences +20

The Chlamydia psittaci Inclusion Membrane Protein 0556 Inhibits Human Neutrophils Apoptosis Through PI3K/AKT and NF-κB Signaling Pathways

Zhangping He, Jian Xiao, Jianye Wang, +8

Frontiers in Immunology

Treponema pallidum delays the apoptosis of human polymorphonuclear neutrophils through the intrinsic and extrinsic pathways

Jianye Wang, Simin Lu, Kang Zheng, +8

Molecular Immunology

Microbial PathogensHuman Polymorphonuclear NeutrophilsImmunologyCell DeathPathology +16