Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

Haiyan Liu, Ali Javaheri, Rebecca J. Godar, +12

Autophagy

Cell DeathFastingInsulin SignalingObesityMetabolic Syndrome +17

Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation

Kohsuke Kanekura, Takuya Yagi, Alexander J. Cammack, +5

Human Molecular Genetics

Protein FunctionAlzheimer's DiseaseAmyotrophic Lateral SclerosisProtein AssemblyNatural Sciences +13

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Simin Lu, Kohsuke Kanekura, Takashi Hara, +15

Proceedings of the National Academy of Sciences

Calcium-dependent ProteaseApoptosisCalpain 2Cell DeathCytoskeleton +23

Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death

Takashi Hara, Jana Mahadevan, Kohsuke Kanekura, +3

Endocrinology

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Lori L. Bonnycastle, Peter S. Chines, Takashi Hara, +15

Diabetes

Wolfram Syndrome 1GeneticsGenetic EpidemiologyPathologyUnaffected Family Members +16

Dominant ER Stress–Inducing <i>WFS1</i> Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts

Elisa De Franco, Sarah E. Flanagan, Takuya Yagi, +13

Diabetes

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism

Jiyeon Lee, Alexis N. Harris, Christopher L. Holley, +13

Journal of Clinical Investigation

Metabolic SyndromeSmall Nucleolar RnasSystems BiologyPancreatic IsletsGlucose Metabolism +13

Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats

Jana Mahadevan, Susan Parazzoli, Elizabeth Oseid, +7

Diabetes

Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet–induced oxidative stress

Tsehay Abebe, Jana Mahadevan, Lindsey D. Bogachus, +6

JCI Insight

Lipid PeroxidationImmunologyCell Deathβ Cell FunctionInsulin Levels +24

Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

Amy L. Clark, Kohsuke Kanekura, Zeno Lavagnino, +7

Scientific Reports