Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

Jian Liu, Adeline Divoux, Jiusong Sun, +13

Nature Medicine

ObesityMetabolic SyndromeInflammationNutritionMast Cell Disorder +10

Mast cells promote atherosclerosis by releasing proinflammatory cytokines

Jiusong Sun, Galina K. Sukhova, Paul J. Wolters, +6

Nature Medicine

InflammationCytokineMast Cell DisorderImmunologyMast Cells +4

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Eloah Rabello Suarez, De-Kuan Chang, Jiusong Sun, +5

Oncotarget

ImmunologyAntigen ProcessingImmunotherapeuticsT CellsImmunotherapy +15

Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors

Bing Wang, Jiusong Sun, Shiro Kitamoto, +5

Journal of Biological Chemistry

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

Jiusong Sun, Galina K. Sukhova, Min Yang, +12

Journal of Clinical Investigation

Lung InflammationMast Cell DisorderImmunologyImmune RegulationImmunotherapy +18

Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells

Jian Liu, Galina K. Sukhova, Jin-Tian Yang, +9

Atherosclerosis

Regulation of Endothelial Cell Adhesion Molecule Expression by Mast Cells, Macrophages, and Neutrophils

Jie Zhang, Pilar Alcaide, Li Liu, +4

PLoS ONE

Cathepsin L activity controls adipogenesis and glucose tolerance

Min Yang, Yaou Zhang, Jiehong Pan, +11

Nature Cell Biology

ObesityMetabolic SyndromeBiochemistryMedicinePhysiology +7

Critical Role of Mast Cell Chymase in Mouse Abdominal Aortic Aneurysm Formation

Jiusong Sun, Jie Zhang, Jes S. Lindholt, +11

Circulation

Cathepsin L Deficiency Reduces Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor–Knockout Mice

Shiro Kitamoto, Galina K. Sukhova, Jiusong Sun, +9

Circulation