Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

Hideki Abe, N Yamada, Katsuo Kamata, +10

Journal of Clinical Investigation

HypertensionHyperlipidemiaGlucose ToleranceInsulin SignalingEndothelium-dependent Vascular Relaxation +19

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.

Masako Shimada, S Ishibashi, T Inaba, +6

Proceedings of the National Academy of Sciences

Lipoprotein LipaseLpl/ldlrko MiceHyperlipidemiaLdlrko MiceOxidative Stress +16

Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.

Shun Ishibashi, Tomohiro Inaba, Hitoshi Shimano, +7

Journal of Biological Chemistry

ImmunologyHyperlipidemiaHuman Monocyte-derived MacrophagesInflammationMetabolic Syndrome +15

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

Hitoshi Shimano, Jun-ichi Ohsuga, Masako Shimada, +6

Journal of Clinical Investigation

Arterial WallVascular DiseasePathologyHyperlipidemiaDiet-induced Atheroma Formation +18

Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.

Masako Shimada, Hitoshi Shimano, Takanari Gotoda, +5

Journal of Biological Chemistry

Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency.

Takanari Gotoda, N Yamada, M Kawamura, +7

Journal of Clinical Investigation

GeneticsGenetic EpidemiologyLpl GenePathologyMolecular Genetics +16

Human inositol 1,4,5-trisphosphate type-1 receptor, Ins<i>P</i>3R1: structure, function, regulation of expression and chromosomal localization

N Yamada, Y. Makino, Robert A. Clark, +8

Biochemical Journal

Human Insp3r1ImmunologyMolecular BiologyCellular PhysiologyMolecular Pharmacology +17

Effects of Lifestyle Modifications on Patients with Type 2 Diabetes: The Japan Diabetes Complications Study (JDCS) Study Design, Baseline Analysis and Three Year-Interim Report

Hirohito Sone, Akane Katagiri, Shun Ishibashi, +9

Hormone and Metabolic Research

A mutation of the b3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride

Hoon Kim-Motoyama, Koichiro Yasuda, Tsuneo Yamaguchi, +7

Diabetologia

ObesityMetabolic SyndromeAdrenal GlandMetabolic DisorderMedicine +8

Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.

N Yamada, Hitoshi Shimano, Hiroshi Mokuno, +7

Proceedings of the National Academy of Sciences

HyperlipidemiaPlasma CholesterolMetabolic SyndromeLipid DisorderDyslipidemia +14