Katsunori Sakai

Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2<i>H</i>-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ET_A Antagonism

Natsuki Ishizuka, Ken‐ichi Matsumura, Katsunori Sakai et al. · Journal of Medicinal Chemistry · 2002 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Studies on dihydropyridines. III. Synthesis of 4,7-dihydrothieno(2,3-b)pyridines with vasodilator and antihypertensive activities.

Ikuo Adachi, Teruo Yamamori, Yoshiharu Hiramatsu et al. · Chemical and Pharmaceutical Bulletin · 1988 · 58 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Yuji Koriyama, Akihiro Hori, Hisanori Ito et al. · Journal of Medicinal Chemistry · 2021 · 54 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

An Efficient Method for the Preparation of Enantiomerically Pure N-Acylarylsulfonamides Having an Asymmetric Center at the α-Position: Condensation of Acid Chlorides and Arylsulfonamides Under Solid-Liquid Two-Phase Conditions

Natsuki Ishizuka, Ken‐ichi Matsumura, Kunio Hayashi et al. · Synthesis · 2000 · 29 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Development of high-throughput spermidine synthase activity assay using homogeneous time-resolved fluorescence

Koji Enomoto, T. Nagasaki, Akira Yamauchi et al. · Analytical Biochemistry · 2006 · 28 citations

Life Sciences, Biochemistry, Molecular Biology +8