Natsuki Ishizuka

Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2<i>H</i>-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ET_A Antagonism

Natsuki Ishizuka, Ken‐ichi Matsumura, Katsunori Sakai et al. · Journal of Medicinal Chemistry · 2002 · 80 citations · Full text

Pharmaceutical Chemistry, Molecular Pharmacology, Medicinal Chemistry +16

Studies on fused indoles. II. Structural modifications and analgesic activity of 4-aminomethyltetrahydrothiopyrano(2,3-b)indoles.

Susumu Takada, Natsuki Ishizuka, Takashi Sasatani et al. · Chemical and Pharmaceutical Bulletin · 1984 · 54 citations · Full text

Bioorganic Chemistry, Molecular Pain, Organic Chemistry +18

Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent

Masahide Odan, Natsuki Ishizuka, Yoshiharu Hiramatsu et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 51 citations · Full text

Functional Selectivity, Medicine, Available Cb2 Agonist +5

An Efficient Method for the Preparation of Enantiomerically Pure N-Acylarylsulfonamides Having an Asymmetric Center at the α-Position: Condensation of Acid Chlorides and Arylsulfonamides Under Solid-Liquid Two-Phase Conditions

Natsuki Ishizuka, Ken‐ichi Matsumura, Kunio Hayashi et al. · Synthesis · 2000 · 29 citations

Pure N-acylarylsulfonamides, Derivatives, Engineering +14

2,3,4,9-Tetrahydrothiopyrano[2,3-b]indoles: synthesis via an intramolecular indole Grignard reaction and conformational study by 1H and 13C NMR spectroscopy

Natsuki Ishizuka · Journal of the Chemical Society Perkin Transactions 1 · 1990 · 16 citations

Zn Reagent, Nmr Spectroscopy, Biochemistry +12