Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France

Laëtitia Minguez, Julie Pédelucq, Émilie Farcy, +3

Environmental Science and Pollution Research

Environmental ChemistryEngineeringGreen PharmacyMedicineMarine Pollution +10

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey, Damien Hédou, Thomas Fréret, +13

Proceedings of the National Academy of Sciences

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT₄R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

Christophe Rochais, Cédric Lecoutey, Florence Gaven, +17

Journal of Medicinal Chemistry

Drug TargetSerotonergic Subtype 4Neurochemical BiomarkersPeptide ScienceAcetylcholinesterase Inhibitory Effects +17

Acute toxicity of 8 antidepressants: What are their modes of action?

Laëtitia Minguez, Émilie Farcy, Céline Ballandonne, +5

Chemosphere

Substance AbusePsychiatryAddictionPsychotropic MedicationPharmacology +12

Synthesis and Structure–Affinity Relationships of Selective High-Affinity 5-HT₄Receptor Antagonists: Application to the Design of New Potential Single Photon Emission Computed Tomography Tracers

Emmanuelle Dubost⧫, Noé Dumas, Christine Fossey, +11

Journal of Medicinal Chemistry

Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on <i>Daphnia magna</i> Life History Traits

Laëtitia Minguez, Céline Ballandonne, Christiane Rakotomalala, +3

Environmental Science & Technology

Synthesis and evaluation of cytotoxic activities of new guanidines derived from carbazoles

Anna Caruso, Maria Stefania Sinicropi, Jean‐Charles Lancelot, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryCytotoxic ActivitiesMedicineNew GuanidinesPharmacology +4

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer’s disease

Samir Yahiaoui, Katia Hamidouche, Céline Ballandonne, +6

European Journal of Medicinal Chemistry

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineNeurotransmitterMultitarget-directed Ligands +8

Comparison of the sensitivity of seven marine and freshwater bioassays as regards antidepressant toxicity assessment

Laëtitia Minguez, Carole Di Poi, Émilie Farcy, +8

Ecotoxicology

Endocrine DisruptorsFreshwater BioassaysPsychiatryMedicinePsychopharmacology +6

The design of donecopride, a dual 5-HT4R agonist/AChE inhibitor with potential interest for AD treatment

Cédric Lecoutey, Damien Hédou, Thomas Fréret, +13

HAL (Le Centre pour la Communication Scientifique Directe)

Antiparasitic AgentPharmacotherapyAntimicrobial ChemotherapyQuinoline 21Chemical Biology +19