Ali Raoof

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Melissa B. Pappalardi, Kathryn Keenan, Mark Cockerill et al. · Nature Cancer · 2021 · 251 citations · Full text

Hematological Malignancy, Medicine, Acute Myeloid Leukemia +9

Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II

Ali Raoof, Paul Depledge, Niall M. Hamilton et al. · Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

<i>In vitro</i> and <i>in vivo</i> induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore et al. · Haematologica · 2020 · 61 citations · Full text

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

P. Hornyak, Trevor Askwith, Sarah Walker et al. · Biochemical Journal · 2016 · 36 citations · Full text

Medicinal Chemistry, Tdp2 Enzyme Activity, Drug Target +15

Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses

Mehida Alexandre, Abdul Kareem Uduman, Samantha N. Minervini et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2012 · 32 citations

Inflammation, Tumor Biology, Pancreatic Cancer +13