Paul Depledge

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance

Shouming Wang, Adrian Folkes, Irina Chuckowree et al. · Journal of Medicinal Chemistry · 2004 · 79 citations · Full text

Drug Target, Multidrug Resistance, Selective Inhibitors +17

Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II

Ali Raoof, Paul Depledge, Niall M. Hamilton et al. · Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

Malarial parasites and tumour cells are killed by the same component of tumour necrosis serum.

Janice Taverne, N Matthews, Paul Depledge et al. · PubMed · 1984 · 60 citations · Full text

Parasitic Disease, Immunotoxicology, Antiparasitic Agent +19

Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor

Janice Taverne, Paul Depledge, J. H. L. Playfair · Infection and Immunity · 1982 · 57 citations · Full text

Immunotoxicology, Antiparasitic Agent, Malaria +17