The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton, +31

Journal of Medicinal Chemistry

Pi3 KinaseChemoprevention StrategyPharmacotherapyPharmaceutical ChemistryTumor Biology +16

Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance

Shouming Wang, Adrian Folkes, Irina Chuckowree, +14

Journal of Medicinal Chemistry

Drug TargetMultidrug ResistanceSelective InhibitorsPharmacotherapyAntimicrobial Chemotherapy +15

Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II

Ali Raoof, Paul Depledge, Niall M. Hamilton, +16

Journal of Medicinal Chemistry

Malarial parasites and tumour cells are killed by the same component of tumour necrosis serum.

Janice Taverne, N Matthews, Paul Depledge, +1

PubMed

Parasitic DiseaseImmunotoxicologyAntiparasitic AgentMalariaImmunology +17

Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor

Janice Taverne, Paul Depledge, J. H. L. Playfair

Infection and Immunity

ImmunotoxicologyAntiparasitic AgentMalariaImmunologyCell Death +15

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Daniel P. Sutherlin, Stewart Baker, Angelina Bisconte, +32

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicinePharmacologyRational Drug Design +6

Design and Synthesis of New Templates Derived from Pyrrolopyrimidine as Selective Multidrug-Resistance-Associated Protein Inhibitors in Multidrug Resistance

Shouming Wang, Nan Chi Wan, John Harrison, +18

Journal of Medicinal Chemistry

Combinatorial ChemistryNovel TemplatesMultidrug ResistancePharmacotherapyPharmaceutical Chemistry +15

Studies on Quinazolinones as Dual Inhibitors of Pgp and MRP1 in Multidrug Resistance

Shouming Wang, Hamish Ryder, Ian Pretswell, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryDual InhibitorsMedicine +9

Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.

Danielle Boller, Kathrin T. Doepfner, Angela De Laurentiis, +19

PubMed

Novel β-Methoxyacrylates of the 9-Methoxystrobilurin and Oudemansin Classes Produced by the Basidiomycete <i>Favolaschia pustulosa</i>

Keith A. Wood, DAVID A. KAU, Stephen K. Wrigley, +7

Journal of Natural Products