Jules A. Shafer

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Yue‐Ming Li, Min Xu, Ming‐Tain Lai et al. · Nature · 2000 · 869 citations

Life Sciences, Biochemistry, Molecular Biology +14

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

Yue‐Ming Li, Ming‐Tain Lai, Min Xu et al. · Proceedings of the National Academy of Sciences · 2000 · 535 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

David D. Roberts, Sidney D. Lewis, David P. Ballou et al. · Biochemistry · 1986 · 200 citations

Life Sciences, Biochemistry, Chemistry +8

Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases

Z Chen, Yinghui Li, E. Chen et al. · Journal of Biological Chemistry · 1994 · 171 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15

Effect of cysteine-25 on the ionization of histidine-159 in papain as determined by proton nuclear magnetic resonance spectroscopy. Evidence for a histidine-159-cysteine-25 ion pair and its possible role in catalysis

Sidney D. Lewis, Fred A. Johnson, Jules A. Shafer · Biochemistry · 1981 · 155 citations

Life Sciences, Biochemistry, Chemistry +10