K. M. RYAN

Efficient catalytic asymmetric alkylations. 3. A kinetic and mechanistic study of the enantioselective phase-transfer methylation of 6,7-dichloro-5-methoxy-2-phenyl-1-indanone

Dave Hughes, Ulf‐H. Dolling, K. M. RYAN et al. · The Journal of Organic Chemistry · 1987 · 187 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +12

A practical synthesis of (±)-thienamycin

David G. Melillo, I. Shinkai, T. Liu et al. · Tetrahedron Letters · 1980 · 126 citations

Practical Synthesis, Bioorganic Chemistry, Pharmacology +2

A diastereospecific, non-racemic synthesis of the C.10–C.18 segment of FK-506

D. Askin, R. P. Volante, Robert A. Reamer et al. · Tetrahedron Letters · 1988 · 39 citations

Diversity Oriented Synthesis, Biosynthesis, Engineering +8

Further studies on the acetonedicarboxylate route to thienamycin—stereochemical inversion at the lactone stage.

David G. Melillo, T. Liu, K. M. RYAN et al. · Tetrahedron Letters · 1981 · 38 citations

Biosynthesis, Acetonedicarboxylate Route, Engineering +9

Alkylation of chiral prolinol propionamide enolates with epoxides: Complete reversal of predicted facial selectivity

D. Askin, R. P. Volante, K. M. RYAN et al. · Tetrahedron Letters · 1988 · 37 citations

Biochemistry, Predicted Facial Selectivity, Organic Chemistry +6