J A Bluestone

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

Lymphoid Neoplasia, Autoimmune Disease, Immunology +6

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Deborah J. Lenschow, Lesley Rhee, Neda Ashourian et al. · Immunity · 2000 · 2K citations · Full text

Control Autoimmune Diabetes, Autoimmune Disease, B7/cd28 Costimulation +9

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

Deborah J. Lenschow, Shu‐Chuan Ho, Husain Sattar et al. · The Journal of Experimental Medicine · 1995 · 587 citations · Full text

Immunology, Pathology, Immunotherapy +17

CTLA-4: a negative regulator of autoimmune disease.

Nitin J. Karandikar, Carol L. Vanderlugt, Theresa L. Walunas et al. · The Journal of Experimental Medicine · 1996 · 378 citations · Full text

T-regulatory Cell, Immune Regulation, Immunology +17

Distinct roles of CTLA‐4 and TGF‐β in CD4⁺CD25⁺ regulatory T cell function

Qizhi Tang, Elisa K. Boden, Kammi Henriksen et al. · European Journal of Immunology · 2004 · 371 citations

Adaptive Immune System, T-regulatory Cell, Immune Regulation +20