An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in<i>Pten</i>^+/−mice

Katrina Podsypanina, Richard Lee, Chris Politis, +15

Proceedings of the National Academy of Sciences

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Guoxia Liu, Arianne Papa, Alexander N. Katchman, +14

Nature

Molecular PhysiologySignal TransductionG Protein-coupled ReceptorPhysiologyProximity Proteomics +5

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

Jann N. Sarkaria, Lin Yang, Patrick T. Grogan, +8

Molecular Cancer Therapeutics

Protein Kinase G Phosphorylates Ca_v1.2 α_1cand β₂Subunits

Lin Yang, Sergey I. Zakharov, Andrew M. Bellinger, +2

Circulation Research

Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib <i>in vitro</i>: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways

Chunrong Yu, Bret B. Friday, Jin-Ping Lai, +7

Molecular Cancer Therapeutics

ApoptosisCell DeathPathologyCancer BiologyGlioma +16

Tocilizumab mimotope alleviates kidney injury and fibrosis by inhibiting IL-6 signaling and ferroptosis in UUO model

Lin Yang, Nan Yu, Yuan Liu, +3

Life Sciences

InflammationCytokineFibrosisAutoimmune DiseaseMedicine +11

The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressure.

Garima Gupta, Mohd Azam, Lin Yang, +1

Journal of Clinical Investigation

HypertensionNitric OxideCellular PhysiologyBlood PressureMolecular Pharmacology +18

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

Elaine Y. Wan, Jeffrey S. Abrams, Richard L. Weinberg, +7

Journal of Clinical Investigation

Cardiac MuscleHeart FailureCardiovascular FunctionSodium InfluxCellular Physiology +15

Defining the BK channel domains required for β1-subunit modulation

John Morrow, Sergey I. Zakharov, Lin Yang, +2

Proceedings of the National Academy of Sciences

Cardiac L‐type calcium channel (Ca _v 1.2) associates with γ subunits

Lin Yang, Alexander N. Katchman, John Morrow, +2

The FASEB Journal