J. Dennis Mahuren

Mice lacking tissue non–specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B–6

Katrina G. Waymire, J. Dennis Mahuren, J. Michael Jaje et al. · Nature Genetics · 1995 · 404 citations

Medicine, Neurology, Neuroscience +12

Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.

Michael P. Whyte, J. Dennis Mahuren, Lauri A. Vrabel et al. · Journal of Clinical Investigation · 1985 · 225 citations · Full text

Medicine, Biochemistry, Nutrition +13

Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.

Michael P. Whyte, M Landt, Louise Ryan et al. · Journal of Clinical Investigation · 1995 · 166 citations · Full text

Medicine, Biochemistry, Physiology +7

A versatile cation-exchange procedure for measuring the seven major forms of vitamin B6 in biological samples

Stephen P. Coburn, J. Dennis Mahuren · Analytical Biochemistry · 1983 · 133 citations

Life Sciences, Biochemistry, Analytical Chemistry +11

Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.

Michael P. Whyte, J. Dennis Mahuren, K N Fedde et al. · Journal of Clinical Investigation · 1988 · 109 citations · Full text

Medicine, Biochemistry, Pathology +11