Stephen P. Coburn

Mice lacking tissue non–specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B–6

Katrina G. Waymire, J. Dennis Mahuren, J. Michael Jaje et al. · Nature Genetics · 1995 · 404 citations

Medicine, Neurology, Neuroscience +12

Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

K N Fedde, Libby A. Blair, Julie Silverstein et al. · Journal of Bone and Mineral Research · 1999 · 400 citations · Full text

Medicine, Biochemistry, Bone Metabolism +16

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase

Stéphane Bach, Marie Knockaert, Jens Reinhardt et al. · Journal of Biological Chemistry · 2005 · 349 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Hypophosphatasia: Validation and expansion of the clinical nosology for children from 25years experience with 173 pediatric patients

Michael P. Whyte, Fan Zhang, Deborah Wenkert et al. · Bone · 2015 · 262 citations

Medicine, Child Health, Pediatrics +3

Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.

Michael P. Whyte, J. Dennis Mahuren, Lauri A. Vrabel et al. · Journal of Clinical Investigation · 1985 · 225 citations · Full text

Medicine, Biochemistry, Nutrition +13