K N Fedde

Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

K N Fedde, Libby A. Blair, Julie Silverstein et al. · Journal of Bone and Mineral Research · 1999 · 400 citations · Full text

Medicine, Biochemistry, Bone Metabolism +16

Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia.

Paula S. Henthorn, M Raducha, K N Fedde et al. · Proceedings of the National Academy of Sciences · 1992 · 261 citations

Life Sciences, Genetics, Molecular Genetics +17

Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.

Michael P. Whyte, M Landt, Louise Ryan et al. · Journal of Clinical Investigation · 1995 · 166 citations · Full text

Medicine, Biochemistry, Physiology +7

Matrix vesicles in osteomalacic hypophosphatasia bone contain apatite-like mineral crystals.

H. Clarke Anderson, Howard H.T. Hsu, David C. Morris et al. · PubMed · 1997 · 120 citations

Medicine, Anatomy, Biochemistry +11

Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.

Michael P. Whyte, J. Dennis Mahuren, K N Fedde et al. · Journal of Clinical Investigation · 1988 · 109 citations · Full text

Medicine, Biochemistry, Pathology +11