GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

Minsuk Kim, Mathew J. Platt, Tadao Shibasaki, +5

Nature Medicine

Molecular PharmacologyHypertensionMolecular PhysiologyMedicinePhysiology +10

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

Nobuaki Ozaki, Tadao Shibasaki, Yasushige Kashima, +9

Nature Cell Biology

Signal TransductionRegulated ExocytosisCell TraffickingEndocytic PathwayIntracellular Trafficking +8

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

Tadao Shibasaki, Harumi Takahashi, Takashi Miki, +8

Proceedings of the National Academy of Sciences

Insulin Granule MovementCytoskeletonCellular PhysiologyInsulin SignalingSecretory Granules +17

Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion

Yasushige Kashima, Takashi Miki, Tadao Shibasaki, +4

Journal of Biological Chemistry

Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1

Takashi Miki, Masashi Suzuki, Tadao Shibasaki, +7

Nature Medicine

Molecular PharmacologyPrinzmetal AnginaMolecular PhysiologyAngiogenesisMedicine +11

Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem

Pascal Béguin, Kazuaki Nagashima, Tohru Gonoi, +7

Nature

Signal TransductionMolecular PhysiologySmall G-protein Kir/gemCell SignalingCell Interaction +8

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

Yang Z. De Marinis, Albert Salehi, Caroline Ward, +18

Cell Metabolism

Molecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicinePhysiology +9

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

Changliang Zhang, M Katoh, Tadao Shibasaki, +7

Science

Piccolo, a Ca2+ Sensor in Pancreatic β-Cells

Kei Fujimoto, Tadao Shibasaki, Norihide Yokoi, +6

Journal of Biological Chemistry

Interaction of ATP Sensor, cAMP Sensor, Ca2+ Sensor, and Voltage-dependent Ca2+ Channel in Insulin Granule Exocytosis

Tadao Shibasaki, Yasuhiro Sunaga, Kei Fujimoto, +2

Journal of Biological Chemistry