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A Diketopiperazine Dimer from a Marine-Derived Isolate of <i>Aspergillus </i><i>n</i><i>iger</i>

Simon Ovenden, Gian Sberna, R. M. TAIT et al. · Journal of Natural Products · 2004 · 52 citations

Industrial Mycology, Antifungal Agent, Biochemistry +13

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Frank Ruebsam, Douglas E. Murphy, Chinh Van Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 43 citations

Hcv Ns5b Polymerase, Biochemistry, Tricyclic 5,6-Dihydro-1h-pyridin-2-ones +8

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Yuefen Zhou, Stephen E. Webber, Douglas E. Murphy et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 41 citations · Full text

Medicinal Chemistry, Biochemistry, Viral Polymerase Structure +10

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Stephen E. Webber, Martin T. Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 37 citations · Full text

Hcv Ns5b Polymerase, Medicine, Antiviral Drug Development +4

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Lian‐Sheng Li, Yuefen Zhou, Douglas E. Murphy et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 35 citations

Biochemistry, Medicine, Antiviral Drug Development +8