A Diketopiperazine Dimer from a Marine-Derived Isolate of <i>Aspergillus </i><i>n</i><i>iger</i>

Simon Ovenden, Gian Sberna, R. M. TAIT, +6

Journal of Natural Products

Industrial MycologyAntifungal AgentBiochemistryKnown Compounds Tmc-256a1Gross Structure +11

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Frank Ruebsam, Douglas E. Murphy, Chinh Van Tran, +29

Bioorganic & Medicinal Chemistry Letters

Hcv Ns5b PolymeraseBiochemistryTricyclic 5,6-Dihydro-1h-pyridin-2-onesMedicineAntiviral Therapy +6

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Yuefen Zhou, Stephen E. Webber, Douglas E. Murphy, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryViral Polymerase StructureNatural SciencesMedicine +8

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Stephen E. Webber, Martin T. Tran, +21

Bioorganic & Medicinal Chemistry Letters

Hcv Ns5b PolymeraseMedicineAntiviral Drug DevelopmentAntiviral DrugPharmacology +2

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Lian‐Sheng Li, Yuefen Zhou, Douglas E. Murphy, +23

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineAntiviral Drug DevelopmentAntiviral TherapyPharmacotherapy +6

Anti-HCV Bioactivity of Pseudoguaianolides from <i>Parthenium hispitum</i>

Jin‐Feng Hu, Rupal Patel, Bin Li, +6

Journal of Natural Products

Medicinal ChemistryAntiviral CompoundBiochemistryHepatitis C VirusViral Hepatitis +13

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

Yuefen Zhou, Lian‐Sheng Li, Peter S. Dragovich, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryViral Polymerase StructureMedicineNatural Sciences +7

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Sun Hee Kim, Martin T. Tran, Frank Ruebsam, +23

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryBiochemistryMedicineOrganic ChemistryStructure-based Design +6

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Chinh Van Tran, Lian‐Sheng Li, +26

Bioorganic & Medicinal Chemistry Letters

Hcv Ns5b PolymeraseMedicineAntiviral Drug DevelopmentAntiviral DrugPharmacology +2

4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

David Ellis, Julie Blazel, Stephen E. Webber, +23

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHcv Ns5b PolymeraseAntiviral Drug DevelopmentAntiviral DrugPharmacology +1