Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Lasse Folkersen, Stefan Gustafsson, Qin Wang, +80

Nature Metabolism

CardiomyopathyHeart FailureCardiovascular DiseaseAtherosclerosisGenetics +7

Inhibition of myostatin in adult mice increases skeletal muscle mass and strength

Lisa-Anne Whittemore, Kening Song, Xiangping Li, +20

Biochemical and Biophysical Research Communications

Animal PhysiologyMechanobiologyMuscle FunctionKinesiologyMuscle Injury +11

Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells

Jill F. Wright, Yongjing Guo, Amira Quazi, +10

Journal of Biological Chemistry

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Jean‐Baptiste Telliez, Martin E. Dowty, Lu Wang, +33

ACS Chemical Biology

Jak1 InhibitionImmunologyImmune RegulationInnate ImmunityInflammatory Arthritis +28

A fluorescent assay suitable for inhibitor screening and vanin tissue quantification

Benfang Helen Ruan, Derek C. Cole, Paul W. Wu, +11

Analytical Biochemistry

Preclinical Drug EvaluationBiochemistryMedicineVanin Tissue QuantificationBioanalysis +9

Acidic Mammalian Chitinase Is Not a Critical Target for Allergic Airway Disease

Lori Fitz, Charlene DeClercq, Jonathan Brooks, +14

American Journal of Respiratory Cell and Molecular Biology

Quantitative measurements of GDF-8 using immunoaffinity LC-MS/MS

Joe Palandra, Amira Quazi, Lori Fitz, +3

PROTEOMICS - CLINICAL APPLICATIONS

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line

Kieran F. Geoghegan, Xi Song, Lise R. Hoth, +6

Protein Expression and Purification

InflammationCytokineHost-specific N-glycosylationMedicineImmunology +9

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

Lasse Folkersen, Stefan Gustafsson, Qin Wang, +80

Drug TargetPolygenic RiskImmunologyGenetic EpidemiologyAbstract Circulating Proteins +23