The Human Serum Paraoxonase/Arylesterase Gene (PON1) Is One Member of a Multigene Family

S.L. Primo-Parmo, Robert C. Sorenson, John F. Teiber, +1

Genomics

BiochemistryGenetic DisorderMedicineGeneticsNatural Sciences +6

Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants

Michael Aviram, Mira Rosenblat, Scott S. Billecke, +5

Free Radical Biology and Medicine

BiochemistryLipid PeroxidationBioanalysisPhysiologyClinical Chemistry +6

Paraoxonase Active Site Required for Protection Against LDL Oxidation Involves Its Free Sulfhydryl Group and Is Different From That Required for Its Arylesterase/Paraoxonase Activities

Michael Aviram, Scott S. Billecke, Robert C. Sorenson, +7

Arteriosclerosis Thrombosis and Vascular Biology

Aldo-keto ReductaseLipid PeroxidationFree Sulfhydryl GroupRedox BiologyOxidative Stress +14

Human Serum Paraoxonase/Arylesterase’s Retained Hydrophobic<i>N</i>-Terminal Leader Sequence Associates With HDLs by Binding Phospholipids

Robert C. Sorenson, Charles L. Bisgaier, Michael Aviram, +3

Arteriosclerosis Thrombosis and Vascular Biology

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.

Robert C. Sorenson, S.L. Primo-Parmo, Chien-Hung Kuo, +3

Proceedings of the National Academy of Sciences

EngineeringMammalian ParaoxonaseBiochemistryCysteine EsteraseNatural Sciences +12

Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study

Albert S Khouri, Janet B. Serle, Jason Bacharach, +56

American Journal of Ophthalmology

The Genetic Mapping and Gene Structure of Mouse Paraoxonase/Arylesterase

Robert C. Sorenson, S.L. Primo-Parmo, Sally A. Camper, +1

Genomics

Cellular EnzymologyGeneticsBiochemical GeneticsMolecular BiologyGene Structure +3

Properties of the retained N-terminal hydrophobic leader sequence in human serum paraoxonase/arylesterase

Robert C. Sorenson, Michael Aviram, Charles L. Bisgaier, +3

Chemico-Biological Interactions

Protein ChemistryCellular EnzymologyBiochemistryNatural SciencesBioanalysis +5

Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase

Jonathan A. Doorn, Robert C. Sorenson, Scott S. Billecke, +2

Chemico-Biological Interactions

Cellular EnzymologyBiochemistryHuman Paraoxonase/arylesteraseHistidine ResiduesHydrolytic Activity +3

Phase 3 Randomized Clinical Trial of the Safety and Efficacy of Travoprost Intraocular Implant in Patients with Open-Angle Glaucoma or Ocular Hypertension

Steven R. Sarkisian, Robert Edward T. Ang, Andy M. Lee, +37

Ophthalmology

Randomized Clinical TrialOcular DiseaseOphthalmologyEye HealthSurgery +4