Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

Mimi N. Phan, Holly A. Leddy, Bartholomew J. Votta, +6

Arthritis & Rheumatism

Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

Uma Prabhakar, David B. Lipshutz, Joan O'Leary Bartus, +4

International Journal of Immunopharmacology

Molecular PharmacologySignal TransductionBiochemistryMedicinePde Iv +11

The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Pamela A. Haile, Bartholomew J. Votta, Robert W. Marquis, +32

Journal of Medicinal Chemistry

Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions

Sanjay Kumar, Annalisa T. Hand, Janice R. Connor, +13

Journal of Biological Chemistry

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases

Pamela A. Haile, Linda Casillas, Bartholomew J. Votta, +30

Journal of Medicinal Chemistry

Chronic Inflammatory DiseasesDrug TargetImmunologyCell DeathPathology +23

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

Pamela A. Haile, Linda Casillas, Michael J. Bury, +31

ACS Medicinal Chemistry Letters

Identification and characterization of endothelin receptors on rat osteoblastic osteosarcoma cells: down-regulation by 1,25-dihydroxy-vitamin D3.

P Nambi, H.L. Wu, David B. Lipshutz, +1

Molecular Pharmacology

Protein kinase C regulates TNF-alpha production by human monocytes.

Uma Prabhakar, David B. Lipshutz, M Pullen, +3

PubMed

ImmunologyImmune RegulationPathologyCell DeathTnf Alpha +16

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

Curt D. Haffner, Adam K. Charnley, Christopher Aquino, +23

ACS Medicinal Chemistry Letters

A Novel Human Bone Marrow Stroma-Derived Cell Line TF274 Is Highly Osteogenic In Vitro and In Vivo

Uma Prabhakar, Ian E. James, Robert A. Dodds, +8

Calcified Tissue International

Regenerative MedicineTissue EngineeringBone Morphogenic ProteinMedicineStem Cell Mobilization +7