John Sherrill

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</i>)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (PF-06821497)

Pei‐Pei Kung, Patrick Bingham, Alexei Brooun et al. · Journal of Medicinal Chemistry · 2017 · 125 citations · Full text

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

Peter B. Madrid, John Sherrill, Ally P. Liou et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 116 citations

Antiparasitic Agent, Medicine, Heterocycle Chemistry +4

Structure−Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds:  Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics

Barnaby C. H. May, Julie A. Zorn, Juanita Witkop et al. · Journal of Medicinal Chemistry · 2006 · 110 citations · Full text

Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum

Marc O. Anderson, John Sherrill, Peter B. Madrid et al. · Bioorganic & Medicinal Chemistry · 2005 · 78 citations · Full text

Combinatorial Chemistry, Bioorganic Chemistry, Biochemistry +10

Discovery of SIRT3 Inhibitors Using SAMDI Mass Spectrometry

Kaushal Patel, John Sherrill, Milan Mrksich et al. · SLAS DISCOVERY · 2015 · 61 citations · Full text

Medicinal Chemistry, Biochemistry, Lysine Residues +14