Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist

Koki Kato, Keisuke Hirai, Keiji Nishiyama, +6

Neuropharmacology

Signal TransductionFunctional SelectivityMedicinePhysiologyNeurochemical Properties +8

Synthesis of a Novel Series of Tricyclic Indan Derivatives as Melatonin Receptor Agonists

Osamu Uchikawa, K. Fukatsu, Ryosuke Tokunoh, +9

Journal of Medicinal Chemistry

Sleep DisordersPharmacotherapyHeterocycle ChemistryPharmaceutical ChemistryMedicinal Chemistry +16

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

Shinobu Sasaki, Shuji Kitamura, Nobuyuki Negoro, +15

Journal of Medicinal Chemistry

Gpr40 Agonist ActivityInsulin SignalingMetabolic SyndromeMolecular PharmacologyMetabolic Signaling +14

5-Aminocoumarans:  Dual Inhibitors of Lipid Peroxidation and Dopamine Release with Protective Effects against Central Nervous System Trauma and Ischemia

Shigenori Ohkawa, K. Fukatsu, Shokyo Miki, +5

Journal of Medicinal Chemistry

Lipid PeroxidationPharmacotherapyOxidative StressMedicinal ChemistryPharmacological Study +15

Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

Makoto Kamata, Asato Kina, Masaaki Funata, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel Spiro-piperidinesBiochemistryMedicineNatural Sciences +7

Synthesis of a Novel Series of Benzocycloalkene Derivatives as Melatonin Receptor Agonists

K. Fukatsu, Osamu Uchikawa, Mitsuru Kawada, +7

Journal of Medicinal Chemistry

Organic ChemistryHeterocycle ChemistryPharmaceutical ChemistryMedicinal ChemistryAmide Group +14

Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors

Makoto Kamata, Asato Kina, Michiko Tawada, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentSymmetrical ApproachPharmacotherapy +3

In vivo Biological Activity of Antioxidative Aminothiazole Derivatives.

Osamu Uchikawa, K. Fukatsu, Masahiro Suno, +2

Chemical and Pharmaceutical Bulletin

Medicinal ChemistryPharmaceutical SciencePharmacological StudyBiochemistryMedicine +10

Approach to the stereoselective synthesis of melatonin receptor agonist Ramelteon via asymmetric hydrogenation

Toru Yamano, Masayuki Yamashita, Mari Adachi, +6

Tetrahedron Asymmetry

Medicinal ChemistryEnantioselective SynthesisBiochemistryMedicineNatural Sciences +6

Design, synthesis, and structure–activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors

Makoto Kamata, Satoshi Endo, Mitsuo Yamamoto, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDiversity Oriented SynthesisBiochemistryNatural SciencesMedicine +6