Mark C. Guzman

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics

Peter S. Dragovich, Thomas J. Prins, Ru Zhou et al. · Journal of Medicinal Chemistry · 2002 · 142 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a .beta.-strand: potential application to the design of novel inhibitors of proteolytic enzymes

Amos B. Smith, Terence P. Keenan, Ryan C. Holcomb et al. · Journal of the American Chemical Society · 1992 · 134 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics

Peter S. Dragovich, Thomas J. Prins, Ru Zhou et al. · Journal of Medicinal Chemistry · 2003 · 115 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

De Novo Design, Synthesis, and X-ray Crystal Structures of Pyrrolinone-Based .beta.-Strand Peptidomimetics

Amos B. Smith, Mark C. Guzman, Paul A. Sprengeler et al. · Journal of the American Chemical Society · 1994 · 106 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport

Amos B. Smith, Ralph Hirschmann, Alexander Pasternak et al. · Journal of Medicinal Chemistry · 1994 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10