Ryan C. Holcomb

Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a .beta.-strand: potential application to the design of novel inhibitors of proteolytic enzymes

Amos B. Smith, Terence P. Keenan, Ryan C. Holcomb et al. · Journal of the American Chemical Society · 1992 · 134 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

De Novo Design, Synthesis, and X-ray Crystal Structures of Pyrrolinone-Based .beta.-Strand Peptidomimetics

Amos B. Smith, Mark C. Guzman, Paul A. Sprengeler et al. · Journal of the American Chemical Society · 1994 · 106 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Design and synthesis of nonpeptide peptidomimetic inhibitors of renin

Amos B. Smith, Ryouichi Akaishi, D. I. Jones et al. · Biopolymers · 1995 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

An effective synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones

Amos B. Smith, Ryan C. Holcomb, Mark C. Guzman et al. · Tetrahedron Letters · 1993 · 32 citations

Natural Sciences, Chemistry, Medicinal Chemistry +5

An asymmetric synthesis of differentially protected meso-2,6-diaminopimelic acid

Ryan C. Holcomb, Steven R. Schow, Semiramis Ayral‐Kaloustian et al. · Tetrahedron Letters · 1994 · 28 citations

Natural Sciences, Chemistry, Medicinal Chemistry +4