D. Lynn Kirkpatrick

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α

Mei Yee Koh, Taly R. Spivak-Kroizman, Sara Venturini et al. · Molecular Cancer Therapeutics · 2008 · 295 citations · Full text

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Nathan T. Ihle, Robert Lemos, Peter Wipf et al. · Cancer Research · 2008 · 273 citations · Full text

The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

Sarah J. Welsh, Ryan Williams, Anne Birmingham et al. · PubMed · 2003 · 252 citations

Pathology, Redox Biology, Redox Protein +17

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell lung cancer xenografts

Nathan T. Ihle, Gillian Paine-Murrieta, Margareta Berggren et al. · Molecular Cancer Therapeutics · 2005 · 150 citations · Full text

Mechanisms of Inhibition of the Thioredoxin Growth Factor System by Antitumor 2-Imidazolyl Disulfides

D. Lynn Kirkpatrick, Miles Kuperus, Marla Dowdeswell et al. · Biochemical Pharmacology · 1998 · 138 citations

Medicinal Chemistry, Biochemistry, Antiparasitic Agent +7