Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

Amila Suraweera, Olivier J. Bécherel, Philip Chen, +11

The Journal of Cell Biology

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

Roman H. Haefeli, Michael A. Erb, Anja C. Gemperli, +5

PLoS ONE

Lipid PeroxidationMolecular BiologyChemical BiologyRedox BiologyNqo1-dependent Redox Cycling +19

Aprataxin, a novel protein that protects against genotoxic stress

Nuri Gueven

Human Molecular Genetics

Genome InstabilityNatural SciencesGeneticsPathogenesisGenomic Mechanism +13

Fucoidan Extracts Ameliorate Acute Colitis

Qi Ying Lean, Rajaraman Eri, J. Helen Fitton, +2

PLoS ONE

InflammationAnti-inflammatoryDextran Sulphate SodiumMucosal ImmunologyMedicine +6

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM

Heather Beamish, Padmini S. Kedar, Hideo Kaneko, +10

Journal of Biological Chemistry

Blm DefectiveGeneticsRadiation EffectMolecular BiologyMolecular Genetics +16

Idebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber’s Hereditary Optic Neuropathy

Fabrice D. Heitz, Michael A. Erb, Corinne Anklin, +3

PLoS ONE

Ocular DiseaseRetinal DamageOptogeneticsOxidative StressRetina +17

Features of Idebenone and Related Short-Chain Quinones that Rescue ATP Levels under Conditions of Impaired Mitochondrial Complex I

Michael A. Erb, Barbara Hoffmann-Enger, H. Deppe, +5

PLoS ONE

Chemical BiologyMitochondrial BiogenesisBiochemistryMitochondrial FunctionComplex Iii +13

ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro

Sergei Kozlov, Nuri Gueven, Katherine E. Keating, +2

Journal of Biological Chemistry

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

Magtouf Gatei, Burkhard Jakob, Philip Chen, +14

Journal of Biological Chemistry

ChromatinGenome InstabilityDna DamageMre11/rad50/nbn ComplexCell Regulation +9

Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study

Patricia Hafner, Beat Erne, Maurice Schmid, +13

PLoS ONE