Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

Shunsuke Kato, Shuang-Yin Han, Wen Liu, +4

Proceedings of the National Academy of Sciences

EngineeringMolecular BiologyFunction–mutation RelationshipsCancer BiologyTumor Biology +15

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients

Masashi Kanai, Yoshihiko Otsuka, Kazunori Otsuka, +12

Cancer Chemotherapy and Pharmacology

Pharmaceutical ScienceOncologyMedicinePharmacotherapyBioavailable Curcumin +5

The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library

Tomohiro Kawaguchi, Shunsuke Kato, Kazunori Otsuka, +5

Oncogene

Somatic VariantNatural SciencesGeneticsDna ReplicationMolecular Biology +5

Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library

Kazuko Shiraishi, Shunsuke Kato, Shuang-Yin Han, +8

Journal of Biological Chemistry

EngineeringGeneticsMolecular BiologyMolecular GeneticsDisease Gene Identification +15

Lack of Correlation between p53-Dependent Transcriptional Activity and the Ability to Induce Apoptosis among 179 Mutant p53s

Yuichi Kakudo, Hiroyuki Shibata, Kazunori Otsuka, +2

Cancer Research

P53-dependent ApoptosisApoptosisCell DeathMolecular BiologyTumor Biology +14

Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer

Hiroo Imai, Hiroshi Soeda, Keigo Komine, +2

BMC Palliative Care

AFP-producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastasis responding to paclitaxel/CDDP: a case report.

Natsuko Chiba, Takashi Yoshioka, Masato Sakayori, +10

PubMed

Esophageal CancerGastroenterologyPathologySerum Afp LevelTumor Biology +16

The screening of the second‐site suppressor mutations of the common p53 mutants

Kazunori Otsuka, Shunsuke Kato, Yuichi Kakudo, +3

International Journal of Cancer

Tumor BiologyGenome InstabilityP53 FunctionEngineeringSecond-site Suppressor +11

Impact of palliative chemotherapy and best supportive care on overall survival and length of hospitalization in patients with incurable Cancer: a 4-year single institution experience in Japan

Yasuko Murakawa, Masato Sakayori, Kazunori Otsuka

BMC Palliative Care

Circulating tumor cell count as a biomarker of a specific gastric cancer subgroup characterized by bone metastasis and/or disseminated intravascular coagulation - an early indicator of chemotherapeutic response

Masahiro Inoue, Kazunori Otsuka, Hiroyuki Shibata

Oncology Letters