The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

Mark Abramovitz, Mohammed Adam, Yves Boie, +16

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Related AnalogsSignal TransductionBiochemistryFunctional SelectivityMedicine +11

Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation

F. Nantel, Danielle Denis, Robert J. Gordon, +4

British Journal of Pharmacology

Discovery of a Potent and Selective Prostaglandin D₂ Receptor Antagonist, [(3<i>R</i>)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[<i>b</i>]indol-3-yl]-acetic Acid (MK-0524)

Claudio F. Sturino, Gary P. O’Neill, Nicolas Lachance, +32

Journal of Medicinal Chemistry

Immunolocalization of cyclooxygenase‐2 in the macula densa of human elderly

F. Nantel, Emily Meadows, Danielle Denis, +3

FEBS Letters

ImmunologyPathologyCox-2 ImmunoreactivityOxidative StressInflammation +14

Structure–activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Hélène Jûteau, Yves Gareau, Marc Labelle, +7

Bioorganic & Medicinal Chemistry

Structure–activity RelationshipMolecular PharmacologyBiochemistryMedicineMechanism Of Action +5

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7 H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

Patsy Clark, Steven E. Rowland, Danielle Denis, +8

Journal of Pharmacology and Experimental Therapeutics

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

Xavier Billot, Anne Châteauneuf, Nathalie Chauret, +6

Bioorganic & Medicinal Chemistry Letters

Signal TransductionBiochemistryFunctional SelectivityMedicineG Protein-coupled Receptor +10

The Immunomodulatory Actions of Prostaglandin E2 on Allergic Airway Responses in the Rat

James G. Martin, Masaru Suzuki, Karim Maghni, +7

The Journal of Immunology

Investigation of the mechanism of non‐turnover‐dependent inactivation of purified human 5‐lipoxygenase

M. David Percival, Danielle Denis, Denis Riendeau, +1

European Journal of Biochemistry

Lipid PeroxidationRedox BiologyOxidative StressHuman 5-LipoxygenaseMetabolism +14

Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis

Christian Beaulieu, Zhaoyin Wang, Danielle Denis, +5

Bioorganic & Medicinal Chemistry Letters

AllergyAntiparasitic AgentAllergy MedicineMedicinePharmacology +8