Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis

Laurent Gomez, Michael D. Hack, Jiejun Wu, +11

Bioorganic & Medicinal Chemistry Letters

Type Ii TopoisomerasesMedicinal ChemistryPharmaceutical ScienceNovel Pyrazole DerivativesMedicine +8

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5<i>H</i>-benzo[5,6]cyclohepta[1,2-<i>b</i>]- pyridin-11(<i>R</i>)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336):  A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

F. George Njoroge, Arthur G. Taveras, Joseph Kelly, +29

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapyPharmaceutical ChemistryTricyclic Ring SystemBromine Atom +16

Electroreductive cyclization. Ketones and aldehydes tethered to .alpha.,.beta.-unsaturated esters (nitriles). Fundamental investigations

R. Daniel Little, Dennis P. Fox, Luc Van Hijfte, +5

The Journal of Organic Chemistry

Chemical EngineeringEngineeringElectroreductive CyclizationDonut IconElectrosynthesis +12

New Sequential Carbon-Carbon Bond Forming Reactions. A Samarium(II) Iodide Mediated Vinylogous Barbier Reaction Followed by an Aldol Reaction

Dennis P. Curran, Ronald Wolin

Synlett

Simple BicycloA SamariumFunctionalized BicycloEngineeringHeterocyclic +13

Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras

Ronald Wolin, David Wang, Joseph Kelly, +4

Bioorganic & Medicinal Chemistry Letters

Oncogenic RasBiochemistryMedicineDrug DevelopmentPharmacology +3

Electroreductive cyclization reactions. Stereoselection, creation of quaternary centers in bicyclic frameworks, and a formal total synthesis of quadrone.

C. Gregory Sowell, Ronald Wolin, R. Daniel Little

Tetrahedron Letters

Inorganic ChemistryChemical EngineeringEngineeringHeterocyclicElectroreductive Cyclization Reactions +7

Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidines as Histamine H₄ Receptor Antagonists

Brad M. Savall, Frank Chavez, Kevin L. Tays, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryAllergyBiochemistryPhase Ii +11

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors

John M. Keith, Leslie A. Gomez, Ronald Wolin, +9

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicinePsychopharmacologyPharmacological AgentNeuropharmacology +4

Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies

Bandarpalle B. Shankar, Brian J. Lavey, Guowei Zhou, +11

Bioorganic & Medicinal Chemistry Letters

Cannabis UseMedicinal ChemistryBiochemistryFunctional SelectivityMedicine +6

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker

Shelby Crawford, Daniel Belajic, Jianmei Wei, +9

Molecular Cancer Therapeutics

ImmunologyImmunotherapyCancer BiologyTumor BiologyInflammation +14