Chris G. Kruse

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

Koen Bossers, Kerstin T.S. Wirz, Gideon F. Meerhoff et al. · Brain · 2010 · 235 citations · Full text

Neurodegenerative Diseases, Systems Biology, Alzheimer's Disease +14

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

Feng Ren, Alex Aliper, Jian Chen et al. · Nature Biotechnology · 2024 · 219 citations · Full text

Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB₁ Cannabinoid Receptor Antagonists

Jos H.M. Lange, Hein K. A. C. Coolen, Herman H. van Stuivenberg et al. · Journal of Medicinal Chemistry · 2003 · 186 citations · Full text

Drug Target, Biological Properties, X-ray Diffraction Study +21

Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors

Femke S. den Boon, Pascal Chameau, Qiluan Schaafsma-Zhao et al. · Proceedings of the National Academy of Sciences · 2012 · 180 citations · Full text

Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant:  Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB₁Cannabinoid Receptor Antagonists

Jos H.M. Lange, Herman H. van Stuivenberg, Hein K. A. C. Coolen et al. · Journal of Medicinal Chemistry · 2004 · 177 citations · Full text

Pyrazole Series, Organic Chemistry, Pharmacotherapy +19