Structural Basis of Severe Acute Respiratory Syndrome Coronavirus ADP-Ribose-1″-Phosphate Dephosphorylation by a Conserved Domain of nsP3

Kumar Singh Saikatendu, Jeremiah S. Joseph, Vanitha Subramanian, +8

Structure

Virus StructureViral ReplicationBiochemistryViral Polymerase StructureConserved Domain +8

Ribonucleocapsid Formation of Severe Acute Respiratory Syndrome Coronavirus through Molecular Action of the N-Terminal Domain of N Protein

Kumar Singh Saikatendu, Jeremiah S. Joseph, Vanitha Subramanian, +4

Journal of Virology

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Teng Teng, Jennifer Tsai, Xiaoling Puyang, +27

Nature Communications

H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma

Jaya Julie Joshi, Heather Coffey, Erik Corcoran, +29

Cancer Research

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Manav Korpal, Xiaoling Puyang, Zhenhua J. Wu, +36

Nature Communications

Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs

Jeremiah S. Joseph, Kumar Singh Saikatendu, Vanitha Subramanian, +9

Journal of Virology

Crystal StructureViral ReplicationViral Polymerase StructureViral Polymerase MechanismViral Pathogenesis +16

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer

Xiaoling Puyang, Craig Furman, Guo Zhu Zheng, +50

Cancer Discovery

Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease nsp15 Suggests a Role for Hexamerization as an Allosteric Switch

Jeremiah S. Joseph, Kumar Singh Saikatendu, Vanitha Subramanian, +4

Journal of Virology

Active Site CleftAllosteric SwitchVirus StructureCrystal StructureViral Replication +13

Nuclear Magnetic Resonance Structure of the N-Terminal Domain of Nonstructural Protein 3 from the Severe Acute Respiratory Syndrome Coronavirus

Pedro Serrano, Margaret A. Johnson, Marcius S. Almeida, +10

Journal of Virology

Virus StructureViral ReplicationNsp3a ExhibitsProtein FoldingN-terminal Domain +10

Identification of a PCSK9-LDLR disruptor peptide with in vivo function

Margaret E. Brousseau, Kevin B. Clairmont, Glen Spraggon, +39

Cell chemical biology

InflammationSignal TransductionPeptide LibraryImmunologyPcsk9-ldlr Disruptor Peptide +5