Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Antonella Sistigu, Takahiro Yamazaki, Erika Vacchelli, +48

Nature Medicine

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityCancer Cell Biology +6

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B. John, Christel Devaud, Connie P.M. Duong, +7

Clinical Cancer Research

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

Melvyn T. Chow, Aleksandra J. Ozga, Rachel L. Servis, +6

Immunity

Tumor BiologyOncologyAnti-pd-1 TherapyCxcr3 Chemokine SystemMedicine +9

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

Christopher J. Chan, Ludovic Martinet, Susan Gilfillan, +7

Nature Immunology

Natural Killer CellsAutoimmune DiseaseImmunologyCell DeathImmunologic Mechanism +7

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

Jaclyn Sceneay, Melvyn T. Chow, Anna Chen, +8

Cancer Research

Blockade of A _2A receptors potently suppresses the metastasis of CD73 ⁺ tumors

Paul A. Beavis, Upulie Divisekera, Christophe Paget, +7

Proceedings of the National Academy of Sciences

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismImmunotherapy +14

NLRP3 Suppresses NK Cell–Mediated Responses to Carcinogen-Induced Tumors and Metastases

Melvyn T. Chow, Jaclyn Sceneay, Christophe Paget, +5

Cancer Research

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismImmunotherapeutics +20

CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

Aleksandra J. Ozga, Melvyn T. Chow, Mateus Eustáquio Lopes, +6

Immunity

InflammationCxcl10 ChemokineT-regulatory CellViral Set PointImmunology +9

CD3^bright signals on γδ T cells identify IL‐17A‐producing Vγ6Vδ1⁺ T cells

Christophe Paget, Melvyn T. Chow, Nicholas A. Gherardin, +17

Immunology and Cell Biology

NLRP3 promotes inflammation‐induced skin cancer but is dispensable for asbestos‐induced mesothelioma

Melvyn T. Chow, Jürg Tschopp, Andreas Möller, +1

Immunology and Cell Biology