Ravindra B. Upasani

3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones:  Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABA_A Receptors

Ravindra B. Upasani, Kevin Yang, Manuel Acosta-Burruel et al. · Journal of Medicinal Chemistry · 1997 · 46 citations · Full text

Discovery of subtype-selective NMDA receptor ligands: 4-Benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1a/2B antagonists

Jon L. Wright, Tracy F. Gregory, Peter A. Boxer et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 21 citations · Full text

Drug Target, Biochemistry, Functional Selectivity +8

Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors.

Jon E. Hawkinson, Manuel Acosta-Burruel, Kevin Yang et al. · PubMed · 1998 · 18 citations

Molecular Pharmacology, Biochemistry, Functional Selectivity +15

Substituted 3β-Phenylethynyl Derivatives of 3α-Hydroxy-5α-pregnan-20-one: Remarkably Potent Neuroactive Steroid Modulators of γ-Aminobutyric AcidA Receptors

Jon E. Hawkinson, Manuel Acosta-Burruel, Kevin Yang et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 12 citations

Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: Potent subtype-selective inhibitors of (NMDA) receptors

Amir P. Tamiz, Edward R. Whittemore, Richard M. Woodward et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 11 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +8