Pamela L. Donner

Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315

Clarissa G. Jakob, Anup K. Upadhyay, Pamela L. Donner et al. · Journal of Medicinal Chemistry · 2018 · 56 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Rolf Wagner, John T. Randolph, Sachin Patel et al. · Journal of Medicinal Chemistry · 2018 · 53 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Pamela L. Donner, Qinghua Xie, John K. Pratt et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 21 citations

Life Sciences, Infectious Diseases, Medicinal Chemistry +16

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a <i>trans</i>-Stilbene Analog with Good Oral Bioavailability

John T. Randolph, A. Chris Krueger, Pamela L. Donner et al. · Journal of Medicinal Chemistry · 2018 · 20 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase

Yaya Liu, Pamela L. Donner, John K. Pratt et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 15 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16