Baochang Zhai

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2<i>H</i>-pyran-4-yl)-1,3-dihydro-2<i>H</i>-imidazo[4,5-<i>c</i>]quinolin-2-one)

Kurt G. Pike, Bernard Barlaam, Elaine Cadogan et al. · Journal of Medicinal Chemistry · 2018 · 116 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 78 citations · Full text

Medicine, Oncology, Pharmacology +17

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

Richard A. Ward, Paul A. Bethel, Calum Cook et al. · Journal of Medicinal Chemistry · 2017 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

Bernard Barlaam, Elaine Cadogan, Andrew D. Campbell et al. · ACS Medicinal Chemistry Letters · 2018 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Water-soluble o-hydroxycinnamate as an efficient photoremovable protecting group of alcohols with fluorescence reporting

Xueyou Duan, Baochang Zhai, Qin‐Hua Song · Photochemical & Photobiological Sciences · 2012 · 22 citations

Natural Sciences, Medicinal Chemistry, Green Chemistry +8