K. L. HAMELEHLE

In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.

BR Krause, Mitchell J. Anderson, C L Bisgaier et al. · Journal of Lipid Research · 1993 · 148 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro.

Judith Sebolt, Sylvia V. Scavone, Cheryl D. Pinter et al. · PubMed · 1987 · 74 citations

Medicine, Oncology, Pharmacology +12

Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo

Drago R. Sliskovic, C. John Blankley, Bruce D. Roth et al. · Journal of Medicinal Chemistry · 1994 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721)

BillyJ. Roberts, K. L. HAMELEHLE, JudithS. Sebolt et al. · Cancer Chemotherapy and Pharmacology · 1986 · 46 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates

H.T Lee, W. Howard Roark, J. A. PICARD et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 21 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15